Anna DeRusso is a graduate of Germantown Academy. From 2016, she studied film acting at the New York Film Academy , and from 2019, she studied film and television communication at Fordham University. She also took dance classes in Manhattan. From 2021, DeRusso appeared in her first short film productions . In 2024, she made her feature film debut in the horror film Monster Mash, produced by The Asylum, playing the role of Pia. That same year, she appeared in several miniseries, including Teaching My Robot Boyfriend How To and Accidental Surrogate for Alpha. She landed a larger role in the horror film Heretics as Mary, in which she and other teenagers enter a cursed house.
