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Notorious Baltimore criminal and underground figure Divine goes up against Connie & Raymond Marble, a sleazy married couple who make a passionate attempt to humiliate her and seize her tabloid-given title as "The Filthiest Person Alive".

When a group of naive teens working at a movie theater in a small Christian town discover a mysterious film hidden in its basement, they unleash an alluring succubus who gives them a sex education…written in blood.

Brandon, a thirty-something man living in New York, eludes intimacy with women but feeds his deepest desires with a compulsive addiction to sex. When his younger sister temporarily moves into his apartment, stirring up bitter memories of their shared painful past, Brandon's life, like his fragile mind, gets out of control.

A white dropout struggles to become a cartoonist and filmmaker, drawing inspiration from the harsh, gritty world around him. Still sharing his rundown apartment with his middle-aged parents, an oafish slob of an Italian father and a ditzy nutcase of a Jewish mother, he's ridiculed and looked down upon by his friends, hypocrites who run with violent gangs and the Italian Mafia, and a shallow Black girl who makes her living downtown with the pimps and pushers. The cartoonist gets a chance to pitch a film idea to a movie mogul, but the story proves too outrageous: a far-future Earth, depleted by war and pollution, where a mutant antihero challenges and kills God.

A duo of bisexual female vampires prey on passing motorists, whom they seduce and murder in the English countryside.