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This documentary follows three women — a fire chief, a judge, and a street missionary — as they battle West Virginia's devastating opioid epidemic.

A young heroin addict roams the streets of New York to panhandle and get her next fix, while her unstable boyfriend drifts in and out of her life at random.

An urgent phone call pulls a Yale Law student back to his Ohio hometown, where he reflects on three generations of family history and his own future.

After he and his first wife separate, journalist David Sheff struggles to help their teenage son, who goes from experimenting with drugs to becoming devastatingly addicted to methamphetamine.

A young drug-addled writer approaching the bottom of his descent submits to two months of agonizing detox at a treatment center in Minnesota.