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During a blizzard in 1964, Dr. David Henry delivers his son Paul with the help of nurse Caroline. But when Henry realizes his wife is also carrying a girl with Down syndrome, he hands the second child over to Caroline without his wife's knowledge. Henry's fateful decision yields grave consequences for his family over the next 20 years.

In 2003, Harvard undergrad and computer programmer Mark Zuckerberg begins work on a new concept that eventually turns into the global social network known as Facebook. Six years later, Mark is one of the youngest billionaires ever, but his unprecedented success leads to both personal and legal complications when he ends up on the receiving end of two lawsuits, one involving his former friend.

A 17-year-old dancer joins a "thinspiration" website and devotes herself to the almost religious glorification of "thin", until she becomes completely possessed by the dark world of anorexia.

When Billy returns from reform school he has to attend a different high school at the other side of town. He tries to start with a clean slate but his old rival doesn't make it easy on him and his buddy Louie tries to make him go astray again. His brother Joe, quite the opposite of Billy, is a good runner and determined to win a track scholarship. He suggests Billy to join his school's track team, which pits the two brothers against each other.

A successful "house tuner" in New York City, who calibrates the sound in people's homes in order to adjust their moods, meets a client with a problem he can't solve.