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Johnny Kovak joins the Teamsters trade-union in a local chapter in the 1930s and works his way up in the organization. As he climbs higher and higher his methods become more ruthless and finally senator Madison starts a campaign to find the truth about the alleged connections with the Mob.

Middle-aged widow Beatrice Hunsdorfer and her daughters Ruth and Matilda are struggling to survive in a society they barely understand. Beatrice dreams of opening an elegant tea room but does not have the wherewithal to achieve her lofty goal. Epileptic Ruth is a rebellious adolescent, while shy but highly intelligent and idealistic Matilda seeks solace in her pets and school projects, including one designed to show how small amounts of radium affect marigolds.

Diego, a Venezuelan urbanist, and Elena, a contemporary dancer from Barcelona, move to the United States with their approved visas to start a new life. Their intention is to boost their professional careers and start a family in 'the land of opportunities'. But upon entering New York airport's immigration area, they are taken to the secondary inspection room, where border officers will subject them to an unpleasant inspection process and a psychologically grueling interrogation.

One summer, Dario flees the hellish environment of his home. Luismi, unconditional friend, a poor devil with pretensions of winning, and Antonia, an old woman who collects abandoned his motorcar furniture, become his new family. Three generations living together in a city too big to be alone.

In the polarized and violent Medellín (Colombia's 'City of Eternal Spring') of the 1970s, doctor Héctor Abad Gómez is concerned about both his children and children from less favored classes. After a devastating loss in the family, Héctor gives himself to the greater cause of public health programs for the poor in Medellín to the consternation of the city's authorities.