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Three friends growing up in South Central Los Angeles navigate a neighborhood plagued by violence, unemployment, and crime, each responding differently to the harsh realities of street life. As tragedy strikes close to home, their friendship, choices, and hopes for a better future are put to the ultimate test.

A seemingly bright and mostly innocent 16-year-old named Mo attempts to navigate high school under the guidance of his best friend Zeke, an unmotivated-yet-charismatic college dropout. Although Zeke genuinely cares about Mo, things start to go awry as he teaches Mo nontraditional life lessons in drug dealing, partying, and dating. Meanwhile, Mo’s well-meaning dad tries to step in and take back the reins of his son’s upbringing.

After moving to a new town, troublemaking teen Jim Stark is supposed to have a clean slate, although being the new kid in town brings its own problems. While searching for some stability, Stark forms a bond with a disturbed classmate, Plato, and falls for local girl Judy. However, Judy is the girlfriend of neighborhood tough, Buzz. When Buzz violently confronts Jim and challenges him to a drag race, the new kid's real troubles begin.

Cagalera and Moloteco are two teenagers from San Gregorio Atlapulco who are desperate to get out and move up and away from oppressive circumstances. When they hear of an opportunity to buy a spot in the electrician’s union, which could transform their lives, they quickly devolve into the criminal, adult underworld of Mexico City in a bid to buy their freedom.

Monica is 13 years old and has already created her own world, on the street, where she fights courageously to defend what little she has: her friends, her boyfriend, who sells drugs, and her dignity and pride that makes no concessions to anyone. On Christmas night, like every night, she sells roses to make a living. But life brings her a new appointment with loneliness, poverty, drugs and death.