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After being found wandering the streets of Los Angeles, a severely catatonic woman tells a doctor the complex story of how she wound up there.

An Oxford Medical School graduate takes a position at a mental institution and soon becomes obsessed with a female mental patient, but he has no idea of a recent and horrifying staffing change.

A brilliant but deranged neurosurgeon becomes obsessively fixated on a judge's daughter. With the help of an escaped criminal whose face he has surgically deformed, the mad man lures her, her father, and her fiancé to his isolated, castle-like home.

Dr. Steven Murphy is a renowned cardiovascular surgeon who presides over a spotless household with his wife and two children. Lurking at the margins of his idyllic suburban existence is Martin, a fatherless teen who insinuates himself into the doctor's life in gradually unsettling ways.

Susannah Cahalan, an up-and-coming journalist at the New York Post becomes plagued by voices in her head and seizures, causing a rapid descent into insanity.