Quién tiene la culpa?!

A group of college students go downstairs to their dorm lobby to get a delivery pizza. There's only one issue: They're insanely high on a homemade drug, turning their simple journey down two sets of stairs into a mind-bendingly transformative quest.

An unemployed pot-smoking slacker and amateur drummer, Anthony Stoner ditches his strict parents and hits the road, eventually meeting kindred spirit Pedro de Pacas. While the drug-ingesting duo is soon arrested for possession of marijuana, Anthony and Pedro get released on a technicality, allowing them to continue their many misadventures and ultimately compete in a rock band contest, where they perform the raucous tune "Earache My Eye."

Jane, a struggling but perpetually stoned actress, has a busy day ahead. She has several important tasks on her list, including buying more marijuana. Even though she already has a good start on the day's planned drug use, she eats her roommate's pot-laced cupcakes and embarks on a series of misadventures all over Los Angeles.

Carly discovers her boyfriend Steven Carson has been cheating on her with Tori Vega, so the gang flies out to Los Angeles where they meet Tori and the gang from Hollywood Arts. They attend a party hosted by Kenan Thompson where Carly and Tori realize Steven was dating them both and therefore cheating on them at the same time, so they plot payback on him.

Four girlfriends take a trip to New Orleans for an annual festival and, along the way, rediscover their wild sides and strengthen the bonds of sisterhood.