After making their way through high school (twice), big changes are in store for officers Schmidt and Jenko when they go deep undercover at a local college. But when Jenko meets a kindred spirit on the football team, and Schmidt infiltrates the bohemian art major scene, they begin to question their partnership. Now they don't have to just crack the case - they have to figure out if they can have a mature relationship. If these two overgrown adolescents can grow from freshmen into real men, college might be the best thing that ever happened to them.

After resolving a situation of exorcism, the half-breed demon hunter Jake Greyman reports to Cardinal White and they realize that the demon Asmodeus is impregnating many mortals trying to raise offspring. Cardinal White calls Sister Sarah Ryan to assist Jake in his hunting for Asmodeus and his women.