The alleged suicide of a gubernatorial candidate triggers a series of mysterious deaths leading to the governor's mansion, and "Wild" Bill McKenzie, a friend of Perry Mason, is on the case.

Perry investigates the murder of a former madam and uncovers a multimillion dollar banking fraud in the process.

Sleazy talk show host Ted Mayne writes a tell-all book, which enrages and embarrasses several very prominent women. One of them, actress Roxanne Shield, loses her composure during an interview and winds up making a televised death threat. Of course, when Ted is murdered, she is arrested. Witnesses claim they saw Roxanne outside his apartment that night and police later find the murder weapon in her car. Renowned defence attorney Perry Mason accepts the challenge of defending her in court.

Ken Malansky, a law student of Perry Mason's, is accused of murdering a fellow student. Perry is reluctant to take on his case as the victim was the son of a close friend.

The owner of a cosmetics company is unveiling a new cream which she claims she's been using. She's been keeping her age a secret and now reveals that she's 60 and owes her appearance to the cream. She's later killed and the formula missing. Her husband is arrested and Perry defends him.

Attorney Bill McKenzie takes the case when his niece is framed for the murder of a popular and demanding sitcom star.

Dr Sheila Carlin is good friends with Della who calls Perry in when she is being pestered by someone. On the theory that it could be somebody that she works with at a radio stations she arranges Perry to be interviewed by Winslow Keene who is also the station's owner. Winslow enrages the rest of the talk show hosts on the station by informing them of changes that he is making to their time slots. That night, Winslow is shot by a hit man hired by someone at the station and Sheila is set up for the murder. She calls in Perry and as usual Perry, Della and Ken swing into action to find out who really did it.

Private investigator Steve is being racketeered by beat cop Melvin Jarvis as divorce client. Silver spoon would be-actor Mark Woodruff is arrested for the shooting of his rich father Nathan. Only one acting class peer, Italian immigrant Isabella, truly believes in his innocence and manages without funds to hire Steve, with widow Marsha as prime suspect. However they soon find an art theft gang is involved, including Mark's youth friends, gallery keeper Brandon and his mate Jamie, who gets shot, and evil brain Alicia.

A homicide detective is assigned to solve a murder case. The trouble is that his wife, a reporter, has been assigned by her employer to cover the same case. Complications ensue.

A young theatre director is accused of killing a more famous Broadway director. Perry takes his case.

A painter, believed to be dead, returns to make allegations that a gallery owner is selling counterfeits of his work. Later, the artist is murdered.

Perry is suing a gutter trash newspaper that is running a story about a love affair between him and Della. The editor also has "dirt" files on an Army General, his banker and other "clients". All of them make little-concealed verbal threats to him at a party but the person that hated him most is a female reporter who the editor had just fired from the paper for attempting to write a serious story. She threatens him and soon after the editor is found, floating in his pool, shot. The reporter is arrested for the crime and Perry, who has a personal stake in this matter, with the aid of Della and Paul set out to solve the mystery. But the other suspects just want the case over with and will go to any lengths to protect their pasts and their secrets

A hockey player of friend of Ken Malansky's is accused of murdering a team owner. Perry takes the case.

The chief suspects in the murder of an author are the numerous colleagues whom he continuously plagiarized.

Perry Mason is invited to the marriage of the daughter of an old friend of his. But after the ceremony the uncle of the bride is dead. Certainly this is a case for Perry Mason.

Perry Mason ventures to Paris to defend a U.S. Marine Corps Captain accused of murdering a man suspected of being a Nazi SS Officer.

After a long search, lawyer Clarke MacGruder finally locates his long lost father Jack. At first, everything seems fine with his new extended family, until the two set off on a hunting trip, where Jack starts showing a rather violent streak to his nature.

Mason defends a man he had sentenced to prison when he was an appellate-court judge. Now, 18 months after the sentencing, a new witness turns up to prove the man's innocence. Mason steps in to defend the man.

A young woman from Las Vegas wants Perry Mason to defend her father.

Anthony Caruso, an old friend of Perry Mason, comes to Denver on the request of Dee Morrison. She's married to famed photographer David Morrison, who wants to shoot a photo featuring his former models. The tricky thing is that all of his former models are also his former wives. But Dee knows Anthony can convince them to do it which he does. And David shoots them. Later Dee catches David it what appears to be in an inappropriate situation with his assistant. They have an argument and she leaves. Later David is found dead and she's arrested and Anthony defends her. And he suspects it could have been one of the wives