Sleazy talk show host Ted Mayne writes a tell-all book, which enrages and embarrasses several very prominent women. One of them, actress Roxanne Shield, loses her composure during an interview and winds up making a televised death threat. Of course, when Ted is murdered, she is arrested. Witnesses claim they saw Roxanne outside his apartment that night and police later find the murder weapon in her car. Renowned defence attorney Perry Mason accepts the challenge of defending her in court.

Ken Malansky, a law student of Perry Mason's, is accused of murdering a fellow student. Perry is reluctant to take on his case as the victim was the son of a close friend.

The alleged suicide of a gubernatorial candidate triggers a series of mysterious deaths leading to the governor's mansion, and "Wild" Bill McKenzie, a friend of Perry Mason, is on the case.

Attorney Bill McKenzie takes the case when his niece is framed for the murder of a popular and demanding sitcom star.

Private investigator Steve is being racketeered by beat cop Melvin Jarvis as divorce client. Silver spoon would be-actor Mark Woodruff is arrested for the shooting of his rich father Nathan. Only one acting class peer, Italian immigrant Isabella, truly believes in his innocence and manages without funds to hire Steve, with widow Marsha as prime suspect. However they soon find an art theft gang is involved, including Mark's youth friends, gallery keeper Brandon and his mate Jamie, who gets shot, and evil brain Alicia.

Dr Sheila Carlin is good friends with Della who calls Perry in when she is being pestered by someone. On the theory that it could be somebody that she works with at a radio stations she arranges Perry to be interviewed by Winslow Keene who is also the station's owner. Winslow enrages the rest of the talk show hosts on the station by informing them of changes that he is making to their time slots. That night, Winslow is shot by a hit man hired by someone at the station and Sheila is set up for the murder. She calls in Perry and as usual Perry, Della and Ken swing into action to find out who really did it.

A homicide detective is assigned to solve a murder case. The trouble is that his wife, a reporter, has been assigned by her employer to cover the same case. Complications ensue.

After a long search, lawyer Clarke MacGruder finally locates his long lost father Jack. At first, everything seems fine with his new extended family, until the two set off on a hunting trip, where Jack starts showing a rather violent streak to his nature.

Perry is suing a gutter trash newspaper that is running a story about a love affair between him and Della. The editor also has "dirt" files on an Army General, his banker and other "clients". All of them make little-concealed verbal threats to him at a party but the person that hated him most is a female reporter who the editor had just fired from the paper for attempting to write a serious story. She threatens him and soon after the editor is found, floating in his pool, shot. The reporter is arrested for the crime and Perry, who has a personal stake in this matter, with the aid of Della and Paul set out to solve the mystery. But the other suspects just want the case over with and will go to any lengths to protect their pasts and their secrets

David Katz is a world famous magician and he comes to Denver with his group to perform for a charity gala for disabled children. Also there is Perry and Della as all three are supporters of the charity. Kate Ford, an assistant with an arrogant attitude, tells David that she is, from now on, going to do an illusion in which an assistant is raised in a glass coffin only to disappear when the coffin is opened up in the air (while the assistant climbs out before the coffin is raised.) After a one night stand with David, Kate is pregnant and she blackmails David with this. David and his wife Judy can't have children so that comes as a double blow to them. However Kate, with her attitude, creates much hatred at her from the rest of the group. At the gala, the glass coffin is raised but when it opens Kate's dead body falls to the ground - strangled.

An editor of a fashion magazine writes a column that destroys careers. She is also a brutal employer. An editor of a rival magazine visits, asking she not be the next victim. The first is found dead and the rival is charged with murder.

A young theatre director is accused of killing a more famous Broadway director. Perry takes his case.

Perry Mason ventures to Paris to defend a U.S. Marine Corps Captain accused of murdering a man suspected of being a Nazi SS Officer.

A painter, believed to be dead, returns to make allegations that a gallery owner is selling counterfeits of his work. Later, the artist is murdered.

Mason defends a man he had sentenced to prison when he was an appellate-court judge. Now, 18 months after the sentencing, a new witness turns up to prove the man's innocence. Mason steps in to defend the man.

Perry investigates the murder of a former madam and uncovers a multimillion dollar banking fraud in the process.

A former associate of Perry Mason returns to handle the defense of a world-class chess player accused of murdering a prominent TV personality.

A gangster who has commited all kinds of crimes is accused to have killed his wife. As he was not the murderer in this case Perry Mason intents to find the killer...

Perry Mason defends the husband of a famous rock singer who was found being killed after having had a tremendous discussion with her husband and her manager.

Perry Mason is invited to the marriage of the daughter of an old friend of his. But after the ceremony the uncle of the bride is dead. Certainly this is a case for Perry Mason.