Sleazy talk show host Ted Mayne writes a tell-all book, which enrages and embarrasses several very prominent women. One of them, actress Roxanne Shield, loses her composure during an interview and winds up making a televised death threat. Of course, when Ted is murdered, she is arrested. Witnesses claim they saw Roxanne outside his apartment that night and police later find the murder weapon in her car. Renowned defence attorney Perry Mason accepts the challenge of defending her in court.

Reformed con man Jack MacShayne is back, this time as the head of security at the Las Vegas hotel he stayed at in MacShayne: Winner Takes All. As part of his new job, he's charged with protecting a variety of distinguished guests, from the kleptomaniac grandson of the hotel's CEO to the lounge singer whose ex-husband shows up dead. Meanwhile, a senatorial candidate is relying on MacShayne to keep him safe from a deadly hit man.

Ken Malansky, a law student of Perry Mason's, is accused of murdering a fellow student. Perry is reluctant to take on his case as the victim was the son of a close friend.

The alleged suicide of a gubernatorial candidate triggers a series of mysterious deaths leading to the governor's mansion, and "Wild" Bill McKenzie, a friend of Perry Mason, is on the case.

Attorney Bill McKenzie takes the case when his niece is framed for the murder of a popular and demanding sitcom star.

Dr Sheila Carlin is good friends with Della who calls Perry in when she is being pestered by someone. On the theory that it could be somebody that she works with at a radio stations she arranges Perry to be interviewed by Winslow Keene who is also the station's owner. Winslow enrages the rest of the talk show hosts on the station by informing them of changes that he is making to their time slots. That night, Winslow is shot by a hit man hired by someone at the station and Sheila is set up for the murder. She calls in Perry and as usual Perry, Della and Ken swing into action to find out who really did it.

A homicide detective is assigned to solve a murder case. The trouble is that his wife, a reporter, has been assigned by her employer to cover the same case. Complications ensue.

An actor rigs a fake shooting on TV with the connivance of his friend, the show's host, but the practical joke goes wrong when the gun turns out to contain a live round.

An editor of a fashion magazine writes a column that destroys careers. She is also a brutal employer. An editor of a rival magazine visits, asking she not be the next victim. The first is found dead and the rival is charged with murder.

A young theatre director is accused of killing a more famous Broadway director. Perry takes his case.

Perry Mason ventures to Paris to defend a U.S. Marine Corps Captain accused of murdering a man suspected of being a Nazi SS Officer.

Jordan White, a publisher friend of Perry, is called to a hotel where a guest, famous horror writer David Hall, has cleared out the hotel for a weekend and has called his "friends" - an actress, a fortune-teller, David's private assistant and the two remaining staff at the hotel to discuss business. They have come to the hotel as all of them are going to sue David over his new book - "The Resort" which characters are obviously based on Jordan and the guests. A practical joker, David plays tricks on them until he is thrown from the high tower of the hotel where Susan Warrenfield, the manager and owner of the hotel sees the fall and then Jordan at the tower causing the police to arrest Jordan. While Perry and Della try to solve the main mystery, Paul tries to find out who is trying to scare Susan away from the hotel. Could it really be a ghost or a more earthy visitor?

David Katz is a world famous magician and he comes to Denver with his group to perform for a charity gala for disabled children. Also there is Perry and Della as all three are supporters of the charity. Kate Ford, an assistant with an arrogant attitude, tells David that she is, from now on, going to do an illusion in which an assistant is raised in a glass coffin only to disappear when the coffin is opened up in the air (while the assistant climbs out before the coffin is raised.) After a one night stand with David, Kate is pregnant and she blackmails David with this. David and his wife Judy can't have children so that comes as a double blow to them. However Kate, with her attitude, creates much hatred at her from the rest of the group. At the gala, the glass coffin is raised but when it opens Kate's dead body falls to the ground - strangled.

A painter, believed to be dead, returns to make allegations that a gallery owner is selling counterfeits of his work. Later, the artist is murdered.

Perry Mason is invited to the marriage of the daughter of an old friend of his. But after the ceremony the uncle of the bride is dead. Certainly this is a case for Perry Mason.

A former associate of Perry Mason returns to handle the defense of a world-class chess player accused of murdering a prominent TV personality.

Perry Mason defends the husband of a famous rock singer who was found being killed after having had a tremendous discussion with her husband and her manager.

A young woman from Las Vegas wants Perry Mason to defend her father.

A gangster who has commited all kinds of crimes is accused to have killed his wife. As he was not the murderer in this case Perry Mason intents to find the killer...

Anthony Caruso, an old friend of Perry Mason, comes to Denver on the request of Dee Morrison. She's married to famed photographer David Morrison, who wants to shoot a photo featuring his former models. The tricky thing is that all of his former models are also his former wives. But Dee knows Anthony can convince them to do it which he does. And David shoots them. Later Dee catches David it what appears to be in an inappropriate situation with his assistant. They have an argument and she leaves. Later David is found dead and she's arrested and Anthony defends her. And he suspects it could have been one of the wives