A handwritten manuscript of Dante Alighieri's poem "The Divine Comedy" makes its way from a priest to a mob boss in New York City, where it is taken by Nick Tosches after he's asked to verify its authenticity.

In post WW2 Venice Italy, American Army Col. Richard Cantwell, haunted by the war, faces news of his illness with stoic disregard. Determined to spend a weekend in quiet solitude, he commandeers a military driver to visit his old haunts in Venice. As Cantwell's plans begin to unravel, a chance encounter with a remarkable young woman begins to rekindle hope. Based on the harrowing novel by Ernest Hemingway.