Driving cross-country, Ray and his wife and daughter stop at a highway rest area where his daughter falls and breaks her arm. After a frantic rush to the hospital and a clash with the check-in nurse, Ray is finally able to get her to a doctor. While the wife and daughter go downstairs for an MRI, Ray, exhausted, passes out in a chair in the lobby. Upon waking up, they have no record or knowledge of Ray's family ever being checked in.

Naoko returns home with her young daughter, where her mother Masako runs the only beauty parlor in town. The local women go there to pass the time lamenting their bad luck with men and laughing over dirty jokes. Unbeknownst to them, Naoko has been secretly seeing her former teacher, Kashima.

After his wife's suicide, Detective Jeff Anderson becomes convinced that she has been murdered. Obsessed with his investigation, he finds out that his wife was the victim of a team of father-and-son serial killers and sets out to stop them.

When their eldest daughter comes of age, a family taking shelter in an isolated rural house must confront the terrifying, deadly creatures that surround them every night.