Brigitte has escaped the confines of Bailey Downs but she's not alone. Another werewolf is tailing her closely and her sister's specter haunts her. An overdose of Monkshood - the poison that is keeping her transformation at bay - leads to her being incarcerated in a rehabilitation clinic for drug addicts where her only friend is an eccentric young girl by the name of Ghost.

The film tells the story of two good friends who live together, Andrew, an agoraphobic travel agent who works from his home, and Dave, a loser who works in an office where he is treated with contempt. Just when it seems things can't get any worse for the two, the entire world outside of their house disappears and is replaced with an endless white void.