American Social Hygiene Association

Childhood friends Mary Lee and Vera receive two different versions of the 'birds and the bees' from their mothers. Mary Lee gets the facts, while Vera gets a prudish fairytale version. Their lives separate after graduation, Mary Lee becomes a nurse who falls in proper love with a Doctor, whereas Vera follows her mother's advice and seeks to marry a rich man, but falls for the unlawful and syphilitic charms of a wealthy cad. Mary Lee and her Doctor rescue Vera and help her get proper care after a series of revelations showing actual patients of the loathsome disease. Finally, Mary Lee and her new husband volunteer to help our boys fighting the Huns in France.

The story of Syphilis and the methods used to detect and fight it. No details about the symptoms though. No mention of penicillin.