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The world-champion in boxing Dany Wagner saves Sandra right before some criminals could give her a shot of heroin to get her addicted. After that he stops a bank robbery with his friend Andreas. They plan to fight the underworld of Nuernberg together.
Two unscrupulous organ mafiosi get stranded in the middle of Nuremberg. Their million-dollar organ shipment burns up in a car accident and they are forced to get new goods. However, they don't reckon with Andreas, Dany and Markus, who have been unbeatable martial arts aces and macho men since the 80s and who once again enforce law and order with a vengeance.
In the final part of the Franconian Macho Man trilogy, Nuremberg faces a huge challenge. A dangerous trafficking cartel has spread across the city and has been up to mischief for years. But the Macho Men, who have been enforcing law and order since the 1980s, are determined to put an end to this cartel.