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The Nutty Professor film's plot centers around individuals with genius-level Intelligence, yet awkward and nerdy social skills. Upon meeting beautiful women, they develop potions that transform them into attractive, confident, albeit villainous alternate personalities who attempt to take over their original counterparts. The series explores the concept of self-worth.
When beautiful Carla Purty joins the university faculty, genetic professor Dr. Sherman Klump grows desperate to whittle his 400-pound frame down to size and win her heart. So, with one swig of his experimental fat-reducing serum, Sherman becomes 'Buddy Love', a fast-talking, pumped-up, plumped down Don Juan.
The hilarity begins when professor Sherman Klump finds romance with fellow DNA specialist, Denise Gaines, and discovers a brilliant formula that reverses aging. But Sherman's thin and obnoxious alter ego, Buddy Love, wants out...and a big piece of the action. And when Buddy gets loose, things get seriously nutty.