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This series follows the transformation of Tomoyuki into the stunning Syuri. Her unique anatomy produces semen with experimental properties that first trigger intense lust in women and later cause the physical feminization of men.
After a string of rejections leaves him depressed, Tomoyuki takes a mysterious "popularity medicine" he bought from a suspicious woman. When he wakes up the next morning, he has been transformed into a beautiful girl named Syuri. Despite the change, his anatomy is larger than ever, and he soon discovers his semen contains potent aphrodisiac ingredients. Now, every woman he encounters is driven into a primal, uncontrollable frenzy by his highly concentrated "horny" essence.
Picking up where the first story left off, Tomoyuki continues his new life as the beautiful, big-dicked girl, Syuri. While the mysterious medicine's initial effect turned him into a stunning woman with potent semen that drove others into a frenzy, a new and more extreme biological side effect has emerged. Syuri discovers that her highly concentrated semen now contains a secondary ingredient that triggers a forced feminization process in any male it touches. As she gives in to her primal instincts, she begins a relentless cycle of depravity, using her unique anatomy to physically transform other men into women against their will.
Akari Mitani has accepted her fate: the 'love potion' has made her female transformation permanent. Now possessed by an oversized member and insatiable lust, she discovers her fluids can transform others into futanari like herself.