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In 1925, Anton Phibes, a horribly disfigured genius, supposedly killed in a car crash, is convinced that his beloved wife died a victim of incompetent doctors, and begins elaborate plans to kill them.
After a team of surgeons botches his beloved wife's operation, the distraught Dr. Phibes unleashes a score of Old-Testament atrocities on his enemies.
The eminent Dr. Phibes awakens from a decade of suspended animation and heads to Egypt with the corpse of his dead wife, which he intends to resurrect by murdering people in strange and heinous ways.